Only recently emerging on our healing horizon, experts predict that stem cells will become the body’s therapeutic miracle workers, regenerating tissues and organs damaged by disease, trauma, or aging. Once thought to be relatively rare or present only in unique tissues, these cells have a ubiquitous presence and regenerative role throughout the body, and may represent a common-denominator mechanism by which many therapies mediate their healing effects.

Because pulling together seemingly disparate pieces of the puzzle catalyzes progress, this discussion summarizes the influence of various adjunct therapies on stem-cell expression. Conceivably, some could augment the effectiveness of the many stem-cell programs emerging throughout the world discussed elsewhere on this site.

Stem-cell transplantation procedures and results vary substantially between programs.  Cells from numerous sources (e.g., blood, bone marrow, olfactory tissue, fetal tissue, etc) have been transplanted via several routes, including into the spinal cord or fluid, intravenously, or intramuscularly. Donor cells are not selected based on the theoretical best source or regenerative potential but their isolation ease, such as concentrating blood stem cells. Likewise, it’s a lot easier and safer but perhaps not as effective to inject cells into a muscle, blood, or spinal fluid than surgically accessing the spinal cord.

In addition, endogenous stem cells may play a healing role in acute injury. For example, Drs. Charles Tator and A.J. Mothe (Neuroscience 131, 2005) have carried out studies in rats suggesting that that injury itself mobilizes dormant spinal-cord stem-cells into action. Perhaps, some of the therapies discussed below could amplify this healing response.

Acupuncture

Traditional Chinese Medicine believes that a life-force energy qi permeates all living things through meridian channels punctuated by acupuncture points. Stimulating these points promotes health- and regeneration-enhancing qi flow.

Scientists have shown that acupuncture influences neuronal stem-cell expression in several animal models of neurological disorders. Because of such suggestive studies, as well as others indicating that acupuncture can restore some function in both acute and chronic human SCI, acupuncture has been incorporated into a number of SCI stem-cell programs.

According to Harvard University’s Dr. Charles Shang, the acupuncture system and stem cells are closely linked through an “organizing center network” composed of under-differentiated, electromagnetically sensitive cells. Confirmed by published studies, this network is created early in embryogenesis before the formation of other body systems (e.g., spinal cord) and has the potential to influence these later-formed systems throughout life. Under this model, acupuncture has extensive growth-control effects and can trigger network stem cells into action. 

As a crude analogy, view the acupuncture-sensitive “organizing center network” as a behind-the-lines’ general ready to send in “green” reserve troops (i.e., stem cells) who will evolve into the front-line combatants replacing those who have fallen from the attacks of disease, trauma, and aging. In the case of transplanted stem cells, Shang speculates that they can be recruited into a new network for repair and regeneration.

Laser

Evidence indicates that laser therapy promotes functional recovery after SCI. For example, Dr. Kimberly Byrnes et al (Washington, DC) demonstrated that laser energy alters gene expression in rats with SCI and in cells being transplanted into the injured cord. Dr. Semion Rochkind (Israel) also has shown that functional recovery in rats with SCI was maximized when embryonic cell transplantation was followed with laser irradiation.

This research is particularly relevant because individuals with SCI have attempted to maximize restored function after stem-cell transplantation using laser-based therapy, especially with the Laserpuncture program developed by France’s Albert Bohbot.  Dr. Emilio Jacques (Mexico) has also used laser and acupuncture therapy after transplanting stem cells into the injury site.

Hyperbaric Oxygen

With hyperbaric oxygen (HBO) therapy, patients are put in chambers pressurized at 2-3 atmospheres containing up to 100% oxygen. Studies suggest that HBO is beneficial for treating a variety of neurological disorders in which blood-flow-related oxygenation is compromised, including acute and perhaps chronic SCI. The premise is that HBO will force oxygen into injured oxygen-deprived CNS tissue. Dr. Stephen Thom et al (Philadelphia, PA) has shown that HBO stimulates the bone-marrow production of stem cells (link). Specifically, stem cells doubled in the circulation of humans after a single two-hour, two-atmosphere HBO session, and after 20 treatments, increased eight-fold.

Omental Surgery

Dr. Harry Goldsmith (Reno, Nevada) has developed surgical procedures for various CNS disorders that use the omentum, a physiologically dynamic tissue that hangs like an apron over the intestines and lower abdomen area (insert link). For SCI, the omentum is surgically tailored to create a pedicle of sufficient length and intact circulation so it can be attached to the cord’s injury site (like cutting a square handkerchief into a long necktie). Dr. Ignacio García-Gómez et al (Madrid, Spain) have shown that human omentum contains stem cells, which synthesize key, blood-flow-enhancing growth factors when transplanted.

Electromagnetic Fields (EMF)

EMF reduces neurological damage after acute SCI. For example, Dr. Wise Young (Piscataway, NJ) reported that the majority of EMF-treated cats with SCI were walking four months after injury compared to none in the control group (insert link). Pilot studies (Poland) suggested that EMF greatly improved neurological outcomes in patients with acute SCI (insert link). Based on these possibilities, several patients who have had stem-cell-containing tissue implanted into their injured cord followed the procedure with EMF therapy.

Because numerous studies indicate EMF influences stem-cell proliferation, including neuronal stem cells, EMF-associated regenerative effects may be partially mediated through such cells. Some speculate that EMF could be the much-needed physiological steering wheel that directs the difficult-to-control, theoretically powerful embryonic stem cells to the desired terminal destination.

Inert-Gas

A little-known therapy, inert-gas treatment builds up the electromagnetic energy fields possessed by all living things, thereby enhancing regenerative potential. Because transplantable stem-cells are living and possess energy fields, some suggest that exposing them to inert-gas energy while in culture will beef-up their physiological robustness and viability before transplantation.

Chemotherapy: Stem-Cell Killer

Recent studies indicate that commonly used chemotherapy agents are more toxic to neuronal stem and progenitor cells than the cancer cells it targets (Dietrich J, et al. J Biol, 5(7), 2006). Due to this toxicity, chemotherapy is associated with many adverse, long-term neurological consequences. Given the incidence of cancer, it is estimated that more people suffer from chemotherapy-related neurological damage than many of the more widely recognized neurological disorders.

Conclusion

Many therapeutic modalities in our healing spectrum can synergistically work together to enhance health if we are open-minded enough to consider the possibilities. If, for example, the world’s most ancient healing tradition, acupuncture, can influence the most state-of-the-art therapy (i.e., stem cells), we should pay attention, or the promising therapeutic potential of this emerging technology may be compromised.

Although we only have a tip-of-the-iceberg understanding of them, stem cells will play an ever-growing role in our efforts to restore function after SCI. As our knowledge increases, ideally, we will be able to take advantage of various adjunct therapies to maximize the healing potential of both transplanted stem cells and those endogenously produced from within. From conception until death, they are the cells of renewal and regeneration through which our healing energies are mediated.

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